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2 edition of Electrophysiology of B-cells from the islets of Langerhans. found in the catalog.

Electrophysiology of B-cells from the islets of Langerhans.

Bambang Kiranadi

Electrophysiology of B-cells from the islets of Langerhans.

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Published by University of East Anglia in Norwich .
Written in English


Edition Notes

Thesis (Ph.D), University of East Anglia, School of Biological Sciences, 1990.

ID Numbers
Open LibraryOL14592715M


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Electrophysiology of B-cells from the islets of Langerhans. by Bambang Kiranadi Download PDF EPUB FB2

Islets of Langerhans contains critical background information, and recent advances made in essentially all areas of islet research. It is a major reference book, the first of its kind, for islet.

The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone-producing) cells, discovered in by German pathological anatomist Paul Langerhans. The pancreatic islets constitute 1 to 2% of the pancreas volume and receive 10–15% of its blood flow.

The pancreatic islets are arranged in density routes throughout the human MeSH: D Islets of Langerhans, irregularly shaped patches of endocrine tissue located within the pancreas of most vertebrates.

They are named for the German physician Paul Langerhans, who first described them in The islets consist of four distinct cell types, of which three produce important hormones.

Drews G., Krippeit-Drews P., Düfer M. () Electrophysiology of Islet Cells. In: Islam M. (eds) The Islets of Langerhans. Advances in Experimental Medicine and Biology, vol Cited by: In book: Islets of Langerhans, 2. (pp) (see also chapter " Electrophysiology of Islet Cells ").

At glucose concentrations below 3 mM, the cell is electrically silent with a resting. The islets of Langerhans comprise approximately % of the weight of the pancreas and are more concentrated in the tail than in the head or body of the pancreas.

Islets can be isolated and separated completely from the exocrine pancreas by the collagenase technique, and the isolated islets will form, store, and release insulin in vitro. This procedure has made it feasible to.

It is a major reference book, the first of its kind, for islet researchers, and diabetes researchers. Anybody, including the experts, and the beginners, interested in the study of islet physiology, and diabetes, will find this book extremely : Hardcover.

Atwater I, Ribalet B, Rojas E () Cyclic changes in potential and resistance of the β-cell membrane induced by glucose in islets of Langerhans from mouse. J Physiol – PubMed PubMedCentral Google Scholar.

Mature pancreatic β-cells can be distinguished from proliferating ones by expression of the Fltp reporter gene, which is triggered by Wnt signalling and β-cell polarization and islet by:   Islets of Langerhans: Known as the insulin-producing tissue, the islets of Langerhans do more than are groups of specialized cells in the pancreas that make and secrete hormones.

Named after the German pathologist Paul Langerhans (), who discovered them inthese cells sit in groups that Langerhans likened to little islands in.

CerfCHAPTER 6: Nutrient regulation of insulin secretion and b-cell functional integrity - Philip Newsholme, Celine Gaudel, and Neville H McClenaghanCHAPTER 7: Electrophysiology of islet cells - Gisela Drews, Peter Krippeit-Drews and Martina DuferCHAPTER 8: ATP sensitive potassium channels in health and disease - Rebecca Clark and Peter.

Direct identification of electrophysiologically monitored cells within intact mouse islets of Langerhans.

Meda P, Santos RM, Atwater I. Cells found to be electrically active within microdissected mouse islets of Langerhans perifused with high (greater than or equal to mM) glucose concentrations were labeled by injecting Lucifer yellow Cited by: "A very timely book on the Islet of Langerhans that coincides with the realization that pancreatic ß-cell failure is key to all forms of diabetes mellitus and research in the field is exploding.

It contains very thoughtful chapters, each by renown experts in their field, and tackles the complexity of this micro-organ in health and disease very Price: $ Beta cells (β cells) are a type of cell found in pancreatic islets that synthesize and secrete insulin and cells make up 50–70% of the cells in human islets.

In patients with type I or type II diabetes, beta-cell mass and function are diminished, leading to Function: Insulin secretion. Get this from a library.

Biophysics of the pancreatic [beta]-cell. [Illani Atwater; Eduardo Rojas; Bernat Soria;] -- Pancreatic B-cell biophysics has undergone a veritable information explosion in the past two years. Single channel and macroscopic currents have become easily accessible following the introduction of.

Pancreatic islets, also called islets of Langerhans, are groups of cells in your pancreas. The pancreas is an organ that makes hormones to help your body break down and use food.

Islets contain several types of cells, including beta cells that make the hormone insulin. Insulin helps your body use glucose for energy and helps control your blood. The islets of Langerhans contain from a few hundred to several thousand hormone-secreting endocrine cells.

The islets are found throughout the pancreas but are most abundant in the tail region of the gland. The human pancreas contains, on average, about 1 million islets, which vary in size from 50 to |xm in diameter. Each islet is separated from the surrounding acinar. Islets of Langerhans and the beginners, interested in the study of islet physiology, and diabetes, will find this book extremely useful.

The book is robust in its breadth: it deals with anatomy, histology, ultra-structure, evolution and comparative anatomy, imaging, developmental biology, programming, apoptosis, mitochondrial function. Sensing any kind of danger in the skin, the Langerhans cells, located in the epidermis and the dermis, are like the air traffic controllers of the immune system.

They send out special agents- immune cells such as T cells and B cells - to capture foreign invaders such as bacteria and viruses, and fight off injuries like cuts and scrapes.

The islets of Langerhans are of vital importance to the body as they produce insulin, a prime regulator of glucose homeostasis. The name ‘islets of Langerhans’ was coined by Edouard Laguesse (–), a histologist working at the University of Lille, who, in a seminal paper incorrectly deduced that they are involved in endocrine.

Islets of Langerhans are micro-organs located in the pancreas and composed of at least four types of endocrine cells. The α- and β-cells are the most abundant and also the most important in that they secrete hormones (glucagon and insulin, respectively) crucial for Cited by: Cerf CHAPTER 6: Nutrient regulation of insulin secretion and b-cell functional integrity - Philip Newsholme, Celine Gaudel, and Neville H McClenaghan CHAPTER 7: Electrophysiology of islet cells - Gisela Drews, Peter Krippeit-Drews and Martina Dufer CHAPTER 8: ATP sensitive potassium channels in health and disease - Rebecca Clark and Peter Proks.

Learn term:insulin glucagon = produced by pancreas with free interactive flashcards. Choose from different sets of term:insulin glucagon = produced by pancreas flashcards on Quizlet.

List the cell types and hormones produced by cells of the islets of Langerhans.-alpha cells = secrete glucagon, ghrelin-beta cells = secrete insulin, proinsulin, C peptide, amylin (invovled in gastric endogens)-gamma cells = secretes somatostatin-epsilon cells = secretes ghrelin.

Preface: Why are Islets so Important. us-Secretion Coupling: Are KATP Channels Enough?:Glucose Recognition: Hexose Recognition by the Pancreatic B-Cell and the Gustatory Cell; A.

Niki, H. Niki. Glucose-Induced Time-Dependent Potentiation and `Run Down' of Insulin Secretion in Islets of Young Rats; C.R. Bliss, G.W.G. Rolefor KATP Channels: ATP.

Supply - Creating More Insulin-Producing Cells. Islet transplantation has clearly shown the ability to restore natural insulin production and normalize blood sugar levels in people with type 1 diabetes. But, some hurdles remain before this cell replacement therapy can be offered more broadly to those who can benefit.

Currently, islets used. We have combined the patch-clamp technique with microfluorimetry of the cytoplasmic Ca2+ concentration ([Ca2+]i) to characterize Na/Ca exchange in mouse β-cells and to determine its importance for [Ca2+]i buffering and shaping of glucose-induced electrical activity.

The exchanger contributes to Ca2+ removal at [Ca2+]i above 1μM, where it accounts for >35% of the total Cited by: Electrophysiology. Electrical activity was recorded from superficial cells in intact pancreatic islets using the perforated patch whole‐cell recording mode as described elsewhere (Göpel et al.

The measurements were performed using an EPC‐9 patch‐clamp amplifier (HEKA Electronics, Lambrecht/Pfalz, Germany) and Pulse (version Cited by: islets.

T h u s, activ ated m acro p h ag es, T H 1 C D 4+ T cells, and b cell-cy to tox ic C D 8+ T cells act sy n er-g istically to de stro y b cells, resu ltin g in aut oim m un e ty p e 1 di ab etes.

K eyw ords: au toim m u n e d iab etes, d estru ction of b cells, b cell au toan tig en s, T cells, m acrop h ag es/ d en - d ritic cells. how is the ultrastructure of alpha and beta cells in the islets of langerhans specialised to their function. One of the questions in my a level biology course and i have no idea what the answer is:S I understand what the alpha and beta cells do - produce the hormones Insulin and Glucagon to control blood sugar levels, but i just don't know how.

Electron Microscope Studies of the Langerhans Islets in the Toad Pancreas. fourth and fifth types. The A- and B-cells are the most common, whereas the third and the fifth type cells are less common and the fourth type cells are the least common. islet cells seem to correspond to the D-cells described in previous electron microscopic Cited by: Capacitance measurements of exocytosis were applied to functionally identified α‐, β‐ and δ‐cells in intact mouse pancreatic islets.

The maximum rate Cited by: LCs complete their maturation and attract T- and B-cells by secrete chemokine which maintain the viability of T lymphocytes 7. Antigen may bind by B-cells, and then both B- and T-cells cluster with mature LCs, but activationin the T-cell area leading the immune : M.

Masthan, N. Anitha, S. Hari Priya, N. Aravindha Babu. 1 Langerhans cells are pre-committed to immune tolerance induction Elena Shklovskayaa, Brendan J. O’Sullivanb, Lai Guan Ngc,d,e, Ben Roedigera,c, Ranjeny Thomasb, Wolfgang Weningerc,d and Barbara Fazekas de St Grotha,d a T Cell Biology Research Program, Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag #6, NSWAustralia.

The glucose-lowering effects of lupin seeds involve the combined action of several components. The present study investigates the influence of one of the main quinolizidine alkaloids, lupanine, on pancreatic beta cells and in an animal model of type-2 diabetes mellitus.

In vitro studies were performed with insulin-secreting INS-1E cells or islets of C57BL/6 by: 8. Islets is the first international, peer-reviewed research journal that will publish manuscripts on all aspects of clinical and experimental research into the physiology and pathology of the Islets of Langerhans and related topics.

We are interested in manuscripts that report new information or insights into any aspects of these micro organs. Islet Pathophysiology in type 1 diabetes Type 1 diabetes is characterized by the appearance of circulating antibodies targeted at beta cell proteins, which appear many years before the onset of clinical disease.

Proteins such as insulin, GAD, IA2, IA-2 beta (phogrin) and CPH (carboxy-peptidase H) are specifically targeted but as.

Cumpără cartea The Islets of Langerhans de Md. Shahidul Islam la prețul de lei, discount 7% cu livrare gratuită prin curier oriunde în Edition: Langerhans cells in skin from patients with psoriasis: quantitative and qualitative study of T6 and HLA-DR antigen-expressing cells and changes with aromatic retinoid administration.

Haftek, M., Faure, M., Schmitt, D., Thivolet, J. Invest. Dermatol. () Establishment of a cell line retaining Langerhans cell characteristics. Gillis, K.D., and Misler, S. Enhancers of cytosolic cAMP augment depolarization induced exocytosis from pancreatic B-cells: evidence for effects distal.

Independent of the aetiopathogenetic mechanism among the different types of diabetes, the common pathway seems to be the inflammation in the pancreatic Langerhans beta cell islets (insulitis), in the concept of an auto-inflammatory process, which results in reduction in both beta cell number and function.

It has been suggested that in Author: Sotirios Tsalamandris, Alexios S Antonopoulos, Evangelos Oikonomou, George-Aggelos Papamikroulis, Ge.The Islet Society is an independent learned society promoting basic and applied researches involving the islets of Langerhans, in the context of diabetes.

Effects of caffeine on cytoplasmic free Ca2+ concentration in pancreatic b-cells are mediated by interaction with ATP-sensitive K+ channels and L-type voltage-gated Ca2+ channels but not Title: Diabetes Researcher at .Polypeptide hormone that is secreted by the islets of Langerhans and, along with glucagon, regulates glucose and metabolic energy sources in the body.

patch clamp electrophysiology Type of T cell that reduces or suppresses the immune response of other T cells (or B .